Aprotinin in extrapleural pneumonectomy: effect on hemostasis and incidence of complications

August 31, 2007

PubMed 

The purpose of this study was to examine the effect of aprotinin on blood loss in extrapleural pneumonectomy and to identify potential treatment-related complications. METHODS: Between March 1, 1999, and July 1, 2004, 27 (52%) of 52 patients who underwent extrapleural pneumonectomy received half-dose aprotinin (1 million kallikrein inhibition units load; 250,000 kallikrein inhibition units per hour infusion). A retrospective data review and analysis were performed. RESULTS: The mean age was 59.8 +/- 11 years, and 45 of 52 patients (87%) were male. Indications for extrapleural pneumonectomy were malignant pleural mesothelioma (n = 50) and pleural-based sarcoma (n = 2). The administration of aprotinin had no significant effect on intraoperative blood loss (1,010 +/- 599 versus 1,182 +/- 688 mL; p = 0.34) or units of packed red blood cells transfused intraoperatively (2.0 +/- 1.7 versus 1.9 +/- 1.7 units; p = 0.86). None of the patients who received aprotinin required the use of non-packed red blood cells blood products, but 4 patients (16%) who did not receive aprotinin required such transfusion (p < 0.05). Postoperative chest tube output at 12 and 24 hours was lower in the aprotinin group (381 +/- 195 and 867 +/- 313 mL, respectively) compared with the control group (725 +/- 527 and 1,221 +/- 442 mL, respectively; p < 0.03). There was no significant difference in incidence of postoperative thromboembolic events between the aprotinin and the control group (5 versus 4 patients; p = 1.0), and 2 patients in each group experienced renal insufficiency (p = 1.0). CONCLUSIONS: Half-dose aprotinin did not decrease intraoperative blood loss or packed red blood cells transfusion in extrapleural pneumonectomy. However, use of aprotinin was associated with decreased use of non-packed red blood cells blood products and lower postoperative chest tube output. Aprotinin administration was not associated with an increase in incidence of postoperative complications.

Ann Thorac Surg. 2007 Sep;84(3):982-6, Bakaeen F, Rice D, Correa AM, Walsh GL, Vaporciyan AA, Putnam JB, Swisher SG, Roth JA, Huh J, Chu D, Smythe WR, The University of Texas, MD Anderson Cancer Center, Houston, Texas, USA. fbakaeen@bcm.edu

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Canada’s asbestos legacy at home and abroad

August 31, 2007

PubMed

Despite international efforts to block Canada’s export of asbestos, the Canadian federal government continues to defend the economic interests of the asbestos industry. Ironically, Canadian asbestos miners, mill workers, and those engaged in a wide range of other occupations continue to suffer asbestos-related disease and premature death. Although there is an employer-funded compensation system in each province, many workers with mesothelioma and other asbestos-related diseases remain uncompensated. The export of Canadian asbestos to developing countries sets the stage for another preventable occupational disease epidemic that will manifest over the coming decades. There is growing support from the Canadian labor movement for an end to asbestos exportation and for a just transition strategy for the asbestos workers and their communities.

Int J Occup Environ Health. 2007 Apr-Jun;13(2):236-43, Brophy JT, Keith MM, Schieman J., Occupational Health Clinics for Ontario Workers (OHCOW), Canada. jbrophy@ohcow.on.ca


Low-dose environmental exposure to crocidolite asbestos increases cancer risk

August 31, 2007

PubMed

This study evaluated the effects of environmental low-dose exposure to crocidolite on people’s health and the society.

The mortality data of cancer between 1994 and 2003 in an environmental crocidolite-contaminated area was obtained from hospital medical records of Dayao Center for Disease Prevention and Control, and Dayao Public Health Bureau. The years of life lost with premature death (YLLs), was used to measure and assess the death, health losses and social burden of cancer in this area. RESULTS: In the environmental crocidolite-contaminated area, lung cancer was the prime cause of death in all kinds of cancers between 1994 and 2003, followed by liver cancer, mesothelioma stomach cancer and colorectal cancer, with mortality 10.15/10(5), 9.04/10(5), 8.48/10(5), 3.96/10(5) and 3.55/10(5) respectively. The mortality of main cancer in male and female increased with age growing except that of breast cancer in female. Results showed that the types of leading cancers of YLLs were liver cancer, lung cancer, mesothelioma, leukemia and stomach cancer with YLLs 1981.39 person-year, 1886.63 person-year, 1799.23 person-year, 948.01 person-year and 754.18 person-year respectively. The distribution of YLLs was similar in both sexes, higher in the middle age group (aged from 15 to 44 years and 45 to 59 years) and lower in other age groups. The indirect economic loss resulting from lung cancer (15.02% of the total loss), liver cancer (13.98% of the total loss) and mesothelioma (13.01% of the total loss) was relatively great. The YLLs and the indirect economic loss attributable to environmental low-dose exposure to crocidolite were 3092.23 person-year and 5,175,800 Yuan respectively.

Lung cancer, liver cancer, mesothelioma, leukemia and breast cancer are the major cancers with an important impact on people’s health and premature mortality in the environmental crocidolite-contaminated area. The impact of cancer mortality is more severer in those aged over 45 years. Social burden of cancer is the greatest in persons aged from 15 to 59 years. Policies and plans should be worked out for the protection of environment and the prevention of cancer.

Zou H, Luo SQ, Yang CY, Zhang MB, Zhejiang Center for Disease Prevention and Control, Hangzhou 310009, China.


Chrysotile asbestos increases risk of lung cancer

August 31, 2007

PubMed

This study investigated the relationship between simple exposure to chrysotile and lung cancer.

The nested case-control study method was used. All of lung cancer cases collected from a male fixed prospective cohort with follow-up of 30 years served as cases and a 1:4 matched proportion was used to select non-cancer case as controls. Controls matched for sex age (+/-5 years old), work time (+/-5 years) and smoking were collected in the same cohort. RESULTS: Forty cases died of lung cancer in the study cohort, and the incidence was higher than the average incidence (SMR =1.77). The top four work types of death density were raw material (741.5), combing and spinning (424.3), weaving (365.0), and repairing (285.5), which was consistent with exposed level. According to the exposed level of chrysotile, the research objects were divided into the high level group and the low level group. The result demonstrated that lung cancer incidence of the high exposed level group of chrysotile was higher (OR = 3.7 95% CI 2.30 approximately 8.16), compared with the low exposed level group.

Simple exposure to chrysotile can increase the risk of lung cancer for workers who are exposed to chrysotile.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2007, Zhou DL, Lan YJ, Wang ZM, Wang MZ, West China School of Public Health, Sichuan University, Chengdu 610041, China.


Drop the State Rock

August 31, 2007

San Pedro, CA – Aug. 30, 2007 – It’s time for California to drop its state rock permanently. The state rock of California, serpentine, is a form of asbestos ore. Asbestos is notorious for indiscriminately killing tens of thousands of people every year without regard to the color of their skin, their social or economic standing, sex, age, occupation, or health.

The Pacific Heart, Lung, and Blood Institute, working with our firm, has taken the lead on contacting legislators and setting up meetings in order to change the law that makes asbestos ore the state rock. You can get involved or voice your support by contacting PHLBI at http://www.phlbi.org.

Asbestos has been called the worst public health crisis in the history of this country. California leads the nation in asbestosis and mesothelioma deaths. Beginning in 1979, when asbestos-related deaths were first tracked, until the end of 2007, the total number of mesothelioma and asbestosis deaths in California will exceed 7,600. Staggeringly, Los Angeles County leads all American counties in deaths from asbestosis and mesothelioma by a wide margin.

The state rock symbolizes a public health catastrophe, particularly since the companies that made and sold asbestos-containing products knew of its deadly consequences, and since the state rock was adopted at the behest of the asbestos mining industry. We refuse to accept this mockery of Californian men, women, and children dying from asbestos poisoning. We ask you to support legislation to get rid of this pernicious state symbol.

Click here to read a letter to legislators. Please feel free to copy and send to your assemblyperson and state senator.

Click here to read a fact sheet about toxic serpentine.

Click here to take a survey about California’s state rock.

Click here to find your California legislators.

Call us for more information: 1-800-831-9399
The Law Office of Roger G. Worthington, P.C.
273 W. 7th Street
San Pedro, CA 90731
http://www.mesothel.com


Asbestos Disease Awareness Organization Newsletter: September 2007

August 23, 2007

Asbestos Disease Awareness Organization

Link to newsletter on ADAO web site 

ADAO Works to Strengthen SB 742, the Ban Asbestos in America Act of 2007

By Paul Zygielbaum

July 31 marked an important step on the road to banning asbestos in the US, when the US Senate Committee on Environment and Public Works (EPW) passed SB 742, the Ban Asbestos in America Act of 2007, for consideration by the full Senate.

In the last weeks before the mark-up session, ADAO volunteers (including my wife, Michelle, and I) met with Senator Patty Murray (D-WA), the author of the bill, and Senator Barbara Boxer (D-CA), who chairs EPW, as well as with their staffs. Working intensively to strengthen and support the bill, ADAO offered key recommendations on the language, which were received enthusiastically and incorporated into the bill as passed by EPW.

The bill had long incorporated ADAO’s recommendation that funding provisions for medical research and treatment cover all forms of asbestos-related disease, not just mesothelioma. At virtually the last minute, the bill also incorporated an amendment proposed by ADAO to address the fact that many products on American markets are believed to contain asbestos as a material contaminant, and not just as an unintentional ingredient. The new language calls for banning not just the use of asbestos, but its very presence in products, as well as mandatory, proactive compliance testing by the EPA of products on the open market and publication of these test results.

In the mark-up session, the EPW unanimously adopted this amendment and then passed the entire bill by unanimous vote. Linda Reinstein, ADAO Executive Director and Cofounder, and Doug Larkin, ADAO Director of Communications & Cofounder, attended the mark-up session to show support from patients, family members and doctors around the world. They were elated by the vote and immediately broke the news of the bill’s passage to our volunteers.

The bill would amend the Toxic Substances Control Act to include asbestos as a banned substance, which previously would require the EPA to respond to individual complaints from the public. With potentially thousands of commercial products currently containing asbestos, this approach would have been cumbersome and costly for the public to undertake, making the ban impractical to enforce. In the verison passed by the EPW, the bill represents a powerful new wall of protection for workers and the public, closing loopholes in previous drafts that could have been exploited by businesses wanting to continue producing products containing asbestos.

The full Senate is expected to take up the bill in September or October. The unexpected bipartisan support in the EPW bodes well for the bill’s chances on the Senate floor. However, the battle is far from over. Opponents are expected to try to amend the ban bill with provisions to control or eliminate asbestos liability lawsuits, along the lines of the so-called “FAIR Act” that was defeated last year. ADAO will maintain vigorous support for the ban and opposition to efforts to taint it with favors for industry.

ADAO expects to advocate for the companion bill that has been introduced in the House of Representatives by Rep. Betty McCollum (D-MN).

U.S. Capitol Tunnel Workers

On August 1st the House Appropriations Subcommittee on the Legislative Branch, Chairwoman, Rep. Debbie Wasserman Schultz (D-FL) and Ranking Member, Rep. Zach Wamp (R-TN) held a Capitol Power Plant Utility Tunnels hearing with Executive Director and Co-Founder Linda Reinstein, Communications Director & Co-Founder Doug Larkin and Executive Assistant & Tunnel Worker Liaison Herman Hamilton in attendance.

The Roll Call Newspaper reported, “Former supervisor of the AOC’s tunnel team, John Thayer, appeared before the subcommittee to talk about the ill effects he, his men and now their families are experiencing as a result of asbestos in the tunnel system. “Our families now have to sit back and watch their loved ones suffer, assuming they don’t get sick from the volume of dust we took home over the years for them to unknowingly breathe,” Thayer said. “The AOC knowingly was aware and left us to suffer in the hazardous environment. … Take care of the men and their families who have given everything they had to support the Congress.”

When asked by Members for some explanation as to how the men and tunnels were ignored for seven years by AOC managers, Ayers – who joined the agency as chief operating officer 18 months ago before taking over the agency – blamed “management breakdowns” and, more specifically, poor internal communications, a lack of independent third-party oversight and a lack of a prioritization system in which life-safety issues could rise to the top.”

View ADAO Press Release

Asbestos Video Library (AVL)

By Dr. Richard Lemen

On August 1, 2007 the Asbestos Disease Awareness Organization was proud to announce the creation of the Asbestos Video Library (AVL). This Library will become the video voice of the organization allowing ADAO to broadcast important conferences, news on developments related to asbestos-disease, announcements of upcoming events, updates on medical treatments and support for asbestos-related disease victims 24 hours a day seven days a week. The AVL and will have an interactive feature to allow viewers to discuss issues with the ADAO as well as post important information for the organization to share with other viewers. We are excited with this new ADAO program for outreach and are sure this will advance the awareness of asbestos-related disease and allow a mechanism for support of those with questions up to now hard to find answers to. We invite all to tune in, learn, and share your input with ADAO.

Volunteer of the Month – Jordan Zevon

Interview with Jordan Zevon, the national spokesperson for ADAO and this month’s chosen volunteer of the month.

Q: How does it feel to be chosen as volunteer of the month?

J: Considering how many people give so much of themselves to this cause, it’s an honor.

Q: What is it that you do for ADAO as the national spokesperson?

J: As the spokesperson I try to make people aware of the dangers that are around them. I try to raise funds and do whatever possible to forward the cause of Asbestos awareness. There are so many incredible doctors and researchers that we work with all the time that what I try to do is to give the human aspect as someone who has suffered the loss and as someone who is terrified of the lack of knowledge.

Q: How is it that you go about doing that?

J: Through fundraising and by spreading the word to any voice that will listen. For example I acquired the web address, http://www.adao.us, that forwards to our original address, http://www.asbestosdiseaseawareness.org, in the hopes that this easier-to-remember web address would get more people to come to the site and enlighten themselves. As strange as it sounds, It’s almost as if I’m selling a product, the difference here is that the product I’m selling is information that could save lives. I perform every year at the ADAO conferences, I publish the address in my CD booklets and I mention it in every interview.

Q: What plans do you have in the future?

J: Eventually when I go on tour, I would like to have an information booth representing ADAO.

Q: So you and Linda went to Washington DC to educate Members of Congress and the national media about Senator Spector’s trust fund legislation and for Asbestos Awareness Day?

J: Yes, it was one of the most amazing experiences of my life, to meet with the Senate Majority Leader Harry Reid and it felt amazing to have a direct voice into an influential ear. And now April 1st is the official Asbestos Disease Awareness Day.

Q: Will continue to perform at the annual ADAO symposium?

J: As long as my schedule allows, I will do whatever Linda asks of me. I’m at her beck and call. She says “jump,” I ask “how high?”

Q: What do you see for the future of ADAO?

J: To find the best ways possible to spread the message about this. For many people, Mesothelioma is just a long, difficult to remember word, that they’ve seen in a late night infomercial where as I like to make people aware and inform them that this isn’t a selective killer. My father was not a factory worker, we have no idea how he got the disease so there’s nothing to say that anybody is immune. And after the tragedy of 9/11 that caused the clouds of toxic dust to pour through the streets of New York, trapped in the atmosphere and deposited around the world, from what I’ve learned in my work with ADAO, I’m horrified for the future. This is one case where saying “I told you so” brings me no joy.

Q: What is your ultimate goal with ADAO?

J: To bring awareness to the level of so many other causes that have been struggling for awareness and ultimately a cure. We have a long road ahead of us and I want to help build a freeway to the cure. It seems that the entertainment industry is such a fixation of the general public nowadays that the best thing I can do is to try and recruit other entertainers for concerts, PSAs or anything possible. Like I said before, it feels strange because I’m almost treating this as a product but whomever takes a moment to look at this product will understand that they can’t live without it because that product is awareness.

Special Feature: Asbestos Plague Reaches Asia

by Laurie Kazan-Allen, IBAS Coordinator

The first anniversary of a landmark Asian conference (Bangkok, Thailand) is being marked with the publication of a dossier exposing the devastating repercussions of Asia’s increasing consumption of asbestos, an acknowledged carcinogen.

Information and data previously unobtainable in the English language form the core of: Killing the Future – Asbestos Use in Asia. An overview of asbestos issues in several countries is presented and regional trends are analyzed, all of which lead the author to conclude that:

“The transference of asbestos technology to industrializing countries is an imperialist act which exploits the world’s most at-risk populations. The continuing use of asbestos is a crime against humanity and cannot be justified.”The text of this report highlights the work of asbestos victims’ groups, pioneering non-governmental organizations and global labor federations in the fight to expose the lethal machinations of the industry lobby. Photographs showing chaotic and hazardous working practices throughout Asia reveal that the reassurance of asbestos stakeholders that asbestos can be used safely under “controlled conditions” is a bald-faced lie.”Millions of global asbestos victims have learned that when it comes to asbestos the polluter rarely pays; the real costs of using this toxic substance are borne by individuals, families, communities and countries. The best way to reduce the burden of asbestos-related disease is to ban asbestos; asbestos is yesterday’s material and should be relegated to the dustbin of discredited technologies and discarded materials,” said author Laurie Kazan-Allen, Coordinator of the IBAS.

For further information, contact Laurie Kazan-Allen, the IBAS Coordinator by email: laurie@lkaz.demon.co.uk or phone: + 44 (0) 208 958 38 87.

2008 Asbestos Awareness Day Conference

The Asbestos Disease Awareness Organization’s 4th Annual Asbestos Awareness Day Conference will be held on March 29 – 30, 2008 in Detroit, Michigan.

The Barbara Ann Karmanos Cancer Institute, a leading comprehensive cancer center in the U.S. will be the venue of the ADAO Conference, Global Mission: Call To Action To Prevent, Detect Treat Asbestos-Related Diseases & Trauma. This event is being made possible by the co-sponsorship of the Barbara Ann Karmanos Cancer Institute, the National Center for Vermiculite and Asbestos-Related Cancers, also based at Karmanos, and the International Ban Asbestos Secretariat (IBAS).

National Center for Vermiculite and Asbestos-Related Cancers Co-Directors are internationally renowned physicians Karmanos President and CEO John C. Ruckdeschel, M.D. and Michael R. Harbut, M.D.,MPH, FCCP, and chief, Center for Occupational and Environmental Medicine.

Conference participants will learn about the most advanced medical, occupational and environmental information available about asbestos related diseases. Presentations will focus on occupational and non-occupational exposure, public health and environmental aspects, early warning symptoms, treatment, trauma and end of life issues.This important international conference is being held to increase awareness of asbestos-related diseases, which kills at least 100,000 workers globally every year.

This important international conference is being held to increase awareness of asbestos-related diseases, which kills at least 100,000 workers globally every year.

Watch for more conference agenda and registration in the fall.

For more information contact : AAD@AsbestosDiseaseAwareness.org

Collegium Ramazzini and the Fight Against Asbestos

By Dr. Arthur Frank

The Collegium Ramazzini, an organization named after the “Father ” of Occupational Medicine, Bernadino Ramazzini, an Italian physician born in Carpi in 1633, is represented by no more than 180 active Fellows, by its charter, and attempts to serve as an educational resource for occupational and environmental issues. One topic that has been of active interest has been the subject of asbestos, and trying to educate the world about its dangers. Two active participants in the Collegium’s activities and writings have been the ADAO Science Advisory Co-chairs Drs. Richard Lemen and Dr. Arthur Frank. The Collegium has written several times and adopted statements regarding the hazards of asbestos, including chrysotile, and has urge the banning of the use of this material. Various Fellows regularly participate in asbestos related activities around the world and include, but are not limited to T.K. Joshi in India, Fernanda Giannasi in Brazil, Elihu Richter in Israel, as well as others. Collaborating with other groups the Collegium, like ADAO, has also had influence in Japan, Thailand, India, and other parts of the developing world. Others have helped with support for Senator Patty Murray’s ban asbestos activities in the U. S. Senate. Many Fellows were signatories to an Amicus brief filed with the Supreme Court of Michigan which lead to a favorable decision about the hazards of asbestos in brakes. It is good to know that ADAO is not alone in its fight to bring to a halt the dangers of asbestos.

International Symposium on Malignant Mesothelioma

The Mesothelioma Applied Research Foundation (MARF) invites you to this year’s International Symposium on Malignant Mesothelioma, which will be held in Washington, DC from October 4th – October 6th. ADAO will be attending the conference again for the 4th year. The MARF conference is an excellent opportunity to meet other patients and caregivers and learn the most advance treatment options.

ADAO reunion information will be posted on our homepage on October 1st.

National PBS Premier on P.O.V – Libby Montana

In the small town of Libby, many hundreds of people are sick or have already died from exposure to asbestos, a notorious industrial toxin that many Americans would consider long banned or under control.

Visit the P.O.V. website and watch additional scenes not included in the film, listen to an interview with journalist Andrew Schneider, who broke the story in Libby on the pages of The Seattle Post-Intelligencer, and watch, or read an interview with filmmakers Drury Gunn Carr and Doug Hawes-Davis (video, podcast and text).

Check your local listings and view trailer

As of the September eNewsletter, Herman Hamilton will no longer be the editor. If you have suggestions or comments, please email info@AsbestosDiseaseAwareness.org. Thanks to Herman, we have an exciting new eNewsletter format!

email: info@asbestosdiseaseawareness.org
web: http://www.ADAO.us

Asbestos Disease Awareness Organization | 1525 Aviation Blvd. Suite 318 | Redondo Beach | CA | 90278


Cancer documentary “Crazy Sexy Cancer” to run on The Learning Channel

August 23, 2007

“Survivors are like tea bags, ya never know how strong we are till you dip us in hot water.” Kris Carr, epithelioid hemangioendothelioma patient, warrior, and survivor.

Kris Carr began making her cancer documentary “Crazy Sexy Cancer” six weeks after being diagnosed, in 2003. It was screened at the South by Southwest film festival in Austin this past March. Read a superb review here.

The Learning Channel will broadcast Crazy Sexy Cancer on August 29.

Click here to view the movie trailer.

Click here to view Kris Carr’s book tour schedule.

Click here to read her blog.