Archive for May, 2007

Bortezomib may help mesothelioma patients

Malignant pleural mesothelioma is resistant to chemotherapy. Bortezomib is an FDA-approved proteasome inhibitor that is currently being studied for its effects on various types of cancer, but has not been studied extensively in mesothelioma.In this report, the researchers determine the biological and molecular response of mesothelioma cells to bortezomib alone and in combination with cisplatin and with pemetrexed (Alimta).

The researchers used mesothelioma cell lines, a normal mesothelial cell line, and a lung cancer cell line in survival studies designed to test the effect of bortezomib on mesothelioma. They also tested bortezomib with cisplatin alone, and with pemetrexed alone. They also tested bortezomib by combining it with Alimta/cisplatin by administering it concurrently or by varying the order of administration.

They determined the effect of bortezomib on: the cell’s life cycle cycle, apoptosis (cell death), on the expression of cell cycle proteins p21/WAF1 and p27/KIP1, and on apoptosis-related proteins IAP-1, IAP-2, survivin, and XIAP. These proteins are important for cells, and if they can be affected in the proper way, the cancer cells will die.

Bortezomib was highly cytotoxic to mesothelioma cells and induced cell cycle arrest. Apoptosis increased in a in 3 of 4 mesothelioma cell lines. Bortezomib stabilized or increased protein levels of p21/WAF1 and IAP-1 and to a lesser degree p27/KIP1, IAP-2, XIAP, and survivin.

In combination studies with cisplatin, bortezomib at high concentrations worked well to kill cancer cells, and did not work well with cisplatin at low concentrations. Bortezomib increased the toxicity of cisplatin and pemetrexed in a concentration-dependent manner when administered prior to either. Bortezomib may improve outcome in pleural mesothelioma patients alone or in combination with standard chemotherapy, but the order of administration is likely to be important. This study justifies further evaluation of bortezomib in MPM.

From: Cancer Chemother Pharmacol. 2007 May 24

Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma.

Gordon GJ, Mani M, Maulik G, Mukhopadhyay L, Yeap BY, Kindler HL, Salgia R, Sugarbaker DJ, Bueno R.

The Thoracic Surgery Oncology Laboratory and the Division of Thoracic Surgery, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis St., Boston, MA, 02115, USA, ggordon@partners.org.

Potential Alimta side effect in mesothelioma patients: severe cutaneous toxicity

Alimta is a chemotherapeutic drug used as first line treatment for malignant pleural mesothelioma in association with Cisplatin, and alone as second line treatment in resistant or relapsing non-small cell lung cancer (NSCLC). However, cutaneous toxicity has been described, principally as a rash. Cutaneous toxicity of all grades has been observed in up to 14%, and grade 3 or 4 toxicity in 0.8-1.3% of cases.

This is a case report of an 85 year-old man treated for NSCLC 15 days after administration of the second cycle of Alimta. The patient had cutaneous lesions including erythema, bullae, and desquamation, associated with deterioration in his general condition; a skin reaction corresponding to Lyell’s syndrome. Treatment with steroids and gammaglobulins led to local resolution and improvement in his general condition.

CONCLUSION: Cutaneous toxicity from Alimta should be recognised on account of its potential severity. The appearance of skin lesions is an indication for careful follow-up for evidence of Lyell’s syndrome for which intensive management is needed.

Article in French by: Tummino C, Barlesi F, Tchouhadjian C, Tasei AM, Gaudy-Marqueste C, Richard MA, Astoul P.

Faculté de Médecine, Université de la Méditerranée-Assistance Publique Hôpitaux de Marseille, Service d’Oncologie Thoracique, Hôpital Sainte-Marguerite, Marseille, France.

 

Criticism increases of EPA advisory panel’s pro-asbestos, anti-mesothelioma victim slant increases

Thursday, 24 May 2007, 03:02 CDT

Asbestos Board in Question: Concerns Raised About Candidates

By Susanne Rust, Milwaukee Journal Sentinel

May 24–Potential panelists for a federal asbestos advisory board have financial conflicts that could pose a threat to public health and safety, according to researchers and environmental groups.

They are concerned about an Environmental Protection Agency board being convened to draft a risk assessment for asbestos fibers. Public comments concerning the panel will close today.

Although the EPA does not regulate asbestos, the agency provides a risk assessment that state and other federal agencies use to define exposure safety. These assessments are used as guides in the cleanup of asbestos-contaminated sites, including Superfund sites.

According to Jennifer Sass of the Natural Resources Defense Council, the recommendations of this panel are “likely to impact federal clean-up standards and may have further impacts on occupational and public health protections in the U.S. and internationally.”

The council and others are particularly concerned with “short list” nominees who have represented corporations such as W.R. Grace & Co. — a company that owned a vermiculite mine in Libby, Mont. The mine was closed in 1990 after reports of asbestos-related illness and death in the town.

The short list of 65 people also includes scientists who either own or work for product defense consulting firms. These are companies hired by corporations and trade associations to influence policy. The defense council is concerned about 12 of the nominees.

“The finances of these scientists are so closely linked to companies affected by federal asbestos policy that they should not be included on a panel whose work will help shape such policy,” wrote David Michaels in a letter to the EPA. He’s is a professor of environmental and occupational health at George Washington University.

The EPA panel is charged with reviewing a new risk assessment model, designed by the agency’s Office of Solid Waste and Emergency Response, which would allow the office to develop site-specific cancer assessments for Superfund sites.

The panel will have no policy or regulatory role. Its advice will be used to inform regulation, not set it, said Tony Maciorowski, deputy director of the EPA’s scientific advisory board office.

Asbestos is a known human carcinogen. Its inhalation has been linked to lung cancer and mesothelioma, a cancer that infects the lining of the lungs and other organs.

According to an internal EPA newsletter, the new model will help determine the carcinogenic potential of asbestos at specific sites and could result in cancer risk assessments that differ from the EPA’s current default.

Watchdog groups are wary about nominees who have argued on behalf of asbestos trade associations for other federal agencies, including the National Institute for Occupational Safety and Health.

On May 4, three of the nominees — Ernest McConnell, president of ToxPath Inc.; Graham Gibbs, president of Safety Health Environment International Consultants; and Wayne Berman, president of Aeolus Inc. — appeared at an Occupational Safety and Health agency meeting to discuss asbestos research. The three nominees advocated on behalf of the National Stone, Sand & Gravel Association, a trade group affected by federal asbestos regulations.

McConnell, who has researched asbestos for federal agencies and industry, said the panel should consist of people who know the most about the issue, regardless of their funding source.

—–

Copyright (c) 2007, Milwaukee Journal Sentinel

Worthington mesothelioma client wins $5.2 million dollar verdict

In Los Angeles Superior Court this week a jury returned a $5.2 million verdict in the case of Walmach vs. Foster Wheeler. This wrongful death case involved Richard Walmach’s bystander exposure to Foster-Wheeler boilers on navy ships that he repaired at Puget Sound Naval Shipyard.

The jury awarded #3.2 million in compensatory damages, and found Foster-Wheeler 30% responsible for the injuries sustained by Walmach. More significantly, they found Foster-Wheeler guilty of malice, and subsequently awarded an additional $2 million in punitive damages.

Foster-Wheeler has instituted a policy of aggressively defending cases brought against it by navy veterans who were exposed to asbestos insulation on their boilers while serving in the navy, and by repairmen who worked on vessels in naval shipyards. Many veterans, like Walmach, go on to develop mesothelioma, an aggressive cancer of the lung’s linings.

Foster-Wheeler’s policy backfired in the case of Richard Walmach. Expert testimony by Dr. Eric Vallieres, as well as Walmach’s own testimony, convinced the jury that Foster-Wheeler’s actions were intentional and indefensible.

Former EPA chief to testify to Congress on fraudulent 9/11 air quality bulletins impacting asbestos, mesothelioma

Government policy will increase asbestos, mesothelioma cancers

Asbestos, Minerals, and United States Policy
by Bill Robbins

An April 19, 2007 decision by the U.S. Court of Appeals (Lombardi v. Whitman) provides stunning insight into the aftermath of the 9/11 attack. Five years after rushing to assist Twin Tower victims, first responders and cleanup workers are dying. The injured participated in search, rescue, and clean-up work at the site with no equipment to protect their lungs. In court documents, the plaintiffs alleged the U.S. Government issued reassuring and knowingly deceptive and misleading statements that the ambient air they inhaled presented no health risks to the public.

The Inspector General of the Environmental Protection Agency (EPA) reported unsafe air continuously detected for weeks after the attack on the Twin Towers. Yet, the White House Council on Environmental Quality routinely edited that information from EPA press releases.

The court’s ruling against the workers affirmed the government’s right to lie, mislead, and omit information in order to insure immediate search, recovery, and clean-up. Moreover, the court claimed the government had a responsibility to create the impression it was safe for people to reside and work in areas near Ground Zero, so they would return to their normal routines. The Court declared that everyone knew, “That one essential government function, in the wake of disaster, is to put the affected community [and nation] on a normal footing.” Preserving the economy (reopening the New York Stock Exchange), restoring services, and avoiding panic were higher priorities than individual or family health.

The extent of human casualties continues to evolve. The administration’s decision to issue false air quality announcements will end more American lives than the terrorists’ attack. Twenty-one thousand workers, and their families, are now suffering from inhaling the building ‘dust.’ Their medical treatment costs are projected to exceed $400 million annually.

New York City rescue workers requested information by way of the Internet, including such questions as “What are the health effects of inhaling this dust from pulverized building materials?” Posted replies alerted the workers to immediately don respirators. The replies described mineral exposure symptoms, and suggested that exposed personnel seek medical treatment and file worker compensation claims. These postings conflicted with government policy and were quickly deleted.

Today, survivors avoid Lower Manhattan. In addition, over 670,000 New Yorkers are still at risk to environmental illnesses.

Minerals indiscriminately kill. Mineral dust, often released during building renovation, takes more lives each day than all the nine-millimeter handguns do in a year. The World Health Organization claims 54% of all worker deaths that result from exposure to workplace carcinogens originated from one mineral source  asbestos. Asbestos is a generic name for six distinct minerals. Over 4,000 industrial applications of these minerals exist, and when inhaled, they are all injurious to your health.

Globally, people who live or work in buildings whose windows do not open and whose entry points are constructed with doorway airlocks are under similar attack. Sealed buildings are seen as a way to reduce energy use and cut operating expense. But, in a sealed building air forced through the ventilation system collects and spreads mineral dust throughout the building. Sick building syndrome and respiratory problems are the fate of those who live or work in such structures. Initial diagnoses often advance into debilitating, life-ending illnesses.

The 9/11 attack and the administration’s appalling response provide an unfortunate observation. Tower responders worked outside, gradually wind and rain dissipated the Ground Zero toxins. Still, one third of the workers have already developed progressive illnesses.

Andrew Robbins is the author of It Took My Breath Away: One Man’s Experience May Save Your Life.

California Superior Court upholds loss of consortium for mesothelioma victim

A recent California appellate decision (Jonnie Lee Pounds v. Crane Co., May 2007) upheld the loss of consortium claim for the wife of a mesothelioma victim poisoned by asbestos. The corporate defendant, Crane Company, argued that since the victim’s exposure to their product ended in 1959, and since the victim and his wife didn’t get married until 1985, the wife couldn’t claim loss of consortium. This specious argument tried to unfairly apply settled law–that loss of consortium claims must be based on a marriage that existed at the time the claim arose–to the unique situation of mesothelioma patients in order to avoid paying legitimate damages.

The reason for the traditional law is that negligent acts and the ensuing injury are almost always closely contemporaneous. If a victim is injured before marriage, his spouse cannot claim that the pre-marital injury deprived her of marital consortium, as both were unmarried and were aware or should have been aware of the injury. The key is that the negligence and the injury happen close together.

The obvious injustice in applying this reasonable law to mesothelioma victims is that the negligent act (being forcibly exposed to asbestos) can be separated from the actual manifestation of injury by as much as 70 years due to the long latency period associated with mesothelioma. Neither husband nor wife will have any inkling that an injury has taken place. In the context of mesothelioma it is extremely difficult to say when the injury occurs. Citing a previous case, the court said that mesothelioma “is a latent, progressively developing disease–decades can often pass between the time a person i sfirst exposed to asbestos and the time he first develops a cancerous mesothelioma tumor. Moreover, although early formation of undetected cellular changes ultimately leads to contraction of the disease, it may be years before the cancerous cells will result in a tumor large enough to be detected, be medically diagnosed, or cause symptomatology of the disease…No temporally discrete event exists that encompasses the defendant’s breach and the plaintiff’s injury.” Buttram v. Owens-Corning Fiberglass Corp. (1997) 16 Cal. 4th 520, 529.

The court concluded that because of the time gap between negligent act and actual injury, the victim’s wife could claim loss of consortium.

MedScape review of peritoneal mesothelioma

Follow this link, and sign up for a free account to register. This is a very good overview of peritoneal mesothelioma, including the disease’s background, its epidemiology, a clinical picture of peritoneal mesothelioma, its diagnosis, pathology, treatment, outcome/prognosis, a conclusion section, with a table and references.

EWG protests mesothelioma apologist’s inclusion on NIOSH short list

May 16, 2007

Ms. Vivian Turner
Designated Federal Officer
Environmental Protection Agency
Via email: turner.vivian@epa.gov
RE: OBJECTION TO ASBESTOS PANEL CANDIDATE
DENNIS C. PAUSTENBACH

Dear Ms. Turner:

Environmental Working Group is disturbed to learn that Dennis C. Paustenbach is on the “Short List” of potential appointees to the Asbestos Panel of the EPA Science Advisory Board. EPA’s Invitation for Comments, dated April 19, 2007, specifies that appointees to the Panel should display “absence of financial conflicts of interest” and “absence of an appearance of a lack of impartiality.” Based on evidence of his work for defendant corporations in lawsuits over asbestos exposure, his studies that consistently aim to refute or minimize the scientifically established risks of asbestos exposure, and other evidence detailed below of a lack of adherence to scientific and professional ethics, it is clear that Dr. Paustenbach is unfit to serve on the Panel.

Dr. Paustenbach has spent virtually his entire career as a paid expert for polluting corporations arguing for weaker health protections for workers and the public from some of the most notorious toxic substances ever known. To our knowledge, Dr. Paustenbach has never argued for greater health protections from any toxic material, regardless of the science base. To the contrary, Dr. Paustenbach has engineered the fabrication of science to absolve a client of major financial liability, in the case of chromium, a fact that contributed to an article produced by Paustenbach’s company being retracted from the Journal of Occupational and Environmental Medicine (JOEM). Paustenbach is legendary in New Jersey where his science, which is now largely discredited, led the state to weaken soil contamination standards for chromium more than a thousand-fold. Now Paustenbach is defending the asbestos industry, leading a science-for-hire campaign to roll back protections from chrysotile asbestos. As we argue below, asbestos is nothing more than a profit center for Paustenbach. It is absurd to think that he will bring any sort of objectivity to the scientific review process on chrysotile carcinogenicity. He has an overwhelming financial interest in only one outcome of this chrysotile review, that which will benefit his clients in the asbestos industry, and is without question unfit to serve on the Panel.

1. CONFLICTS OF INTEREST

Dr. Paustenbach is founder and president of ChemRisk, Inc. As head of this firm, and in previous positions, he has a long history of work for corporations who were defendants in lawsuits over asbestos exposure. His resume on ChemRisk’s web site[1] does not disclose the names of his clients. Last year, in an investigation of auto industry lobbying against federal rules on asbestos brakes, the Baltimore Sun cited documents showing that Chemrisk and Paustenbach’s previous firm, Exponent, were paid more than $23 million since 2001 by Ford, General Motors and Daimler-Chrysler to help fight asbestos lawsuits brought against them by former workers.[2]

In addition, research by the independent Center for Science in the Public Interest[3] has documented the following list of other Paustenbach clients who are or have been defendants in asbestos litigation, or who are associated with such defendants:

Alcoa
Allied Signal
Amoco
ARCO
Beazer Corporation
Chemical Manufacturers Association
Chevron Chemical Company
Dow Chemical
Exxon
FMC
GATX
General Dynamics
General Electric
Gould Industries
Hercules
ICI Americas
Industrial Health Foundation
Koppers
Maxus Energy Corporation
McKesson
Mobil Oil Corporation
Monsanto
Montrose
Rhône Poulenc
Shell
Stauffer Chemicals
Union Carbide
Vulcan Chemicals
Zeneca

2. LACK OF IMPARTIALITY

According to his resume, in 2005 and again in 2006 Dr. Paustenbach was a featured speaker at conferences organized by the Chrysotile Institute and the International Chrysotile Association, formerly the Asbestos Institute and the International Asbestos Association. These are front groups for the asbestos industry. Numerous articles on the Institute’s website make clear that these organizations have a strong bias against the objective evaluation of chrysotile’s health hazards:

“If people preaching the banishment [of chrysotile] were really well informed and were using their contacts with the media, in particular, to make public the good and true news about chrysotile, people would not panic any more. On the contrary, they would be reassured of knowing that many cities of the planet were built, irrigated and supplied out of drinking water thanks to chrysotile products, and this, in full safety. Unfortunately, the poor combat they carry out only propagates quite inaccurate information serving only their economic or ideological interests.[4]“

At the 2006 International Conference on Chryosotile in Montreal, Dr. Paustenbach delivered a presentation entitled “The Roles of Dose Reconstruction and Simulation Studies in Understanding Historical Exposure to Asbestos.” The 30-minute presentation, available in a video file on the Chrysotile Institute’s website,[5] is a thinly veiled pitch for asbestos litigants to hire ChemRisk to conduct simulation studies for their defense. Dr. Paustenbach advises his audience that asbestos juries expect to see such studies, and that the studies asbestos defendants relied on just a few years ago are outdated. Also telling is Dr. Paustenbach’s use of the pronoun “we” to refer to the U.S. asbestos industry’s response to Congress’ proposed creation of a trust fund to cover claims:

“It’s a complex subject, and it takes a lot of work and a lot of money to do them [studies]. But I can assure you it’s worth the effort. To the best of my knowledge in litigation that was traditionally lost in the United States, I’m not aware of a single case that has been lost when a high quality simulation study was done and exposures were considered de minimus.
. . .

“It’s a shame to have to have spent, let’s say, $250,000 to do this study when it’s really intuitive that there wouldn’t be much exposure. But when it costs $4 million in the United States to work up and take a case to trial — that’s just the expenses, that’s not the outcome — a $250,000 or $500,000 study is a drop in the bucket. So when you heard yesterday — remember we turned down a settlement of $150 billion, that’s with a B, to settle the litigation crisis in the United States — these kinds of $250,000, $500,000 investments go a long way. If you’ve got 100 cases and it takes $4 million for the lawyers and consultants to get ready for the case and to take it to trial, you can see it’s a drop in the bucket. So when I hear people say, ÔWe can’t afford it,’ I don’t understand.”

3. LACK OF ADHERENCE TO ETHICAL STANDARDS

In July 2006, the prestigious Journal of Occupational and Environmental Medicine (JOEM) retracted a 1997 study that had appeared to be written solely by two Chinese scientists, JianDong Zhang and ShuKun Li. In reality, the paper was largely written by Dr. Paustenbach’s firm, ChemRisk, while under contract with Pacific Gas & Electric (PG&E). The retraction was specifically for hiding PG&E’s financial sponsorship of the paper as well as ChemRisk’s intellectual input, but there is compelling evidence of wider fraud.

Dr. Paustenbach was CEO of ChemRisk when PG&E hired the company to help defend against a major lawsuit brought by the small town of Hinkley, California. Local residents had sued PG&E, claiming that the utility was responsible for contaminating the town’s drinking water with hexavalent chromium which, in turn, had caused many serious health problems in the community, including cancer.

Zhang and Li’s original paper, published in 1987 by JOEM, had found a strong association between consumption of chromium-6 laced water and stomach, and PG&E wanted to cast doubt on that finding. In 1986, under Dr. Paustenbach’s direction, ChemRisk scientists obtained Zhang and Li’s original data, manipulated it to obscure the connection between chromium-6 in drinking water and cancer and rewrote their paper. Then they submitted it under Zhang’s byline to JOEM, where it was published. JOEM knew nothing of the paper’s real author and funding source until Environmental Working Group exposed the deception last year.

Not long after publication of the 1997 paper, PG&E paid damages of $333 million to settle the Hinkley case, which became the basis for the film Erin Brockovich. But the fraudulent study had a much wider impact, influencing a federal Agency for Toxic Substances & Disease Control guidance document and forcing California regulators to re-evaluate a risk assessment for chromium-6 in drinking water, causing several years’ delay in setting safety standards.

The details of this fraud are well documented in a front-page article in The Wall Street Journal[6] and in our own investigation[7], which includes links to the original documents making the case against Dr. Paustenbach and ChemRisk. They show convincingly that in the chromium-6 case, Dr. Paustenbach violated the code of ethics of the Society of Toxicology, his professional association, by failing to conduct himself with integrity, failing to be honest and truthful in reporting and communicating his research, hiding clear material conflicts of interest, and failing to avoid situations that imply a conflict of interest.

The task before the Asbestos Panel — to provide technical advice on EPA’s proposed methodology to estimate potential cancer risk from inhalation exposure to asbestos — is crucial. EPA’s determination will affect the future health and safety of every American who is exposed to asbestos in the workplace and in consumer products. To ensure that this decision relies on the best objective science, without influence of corporations with a financial stake in the outcome, the Asbestos Panel must be free of all conflict of interest or bias, and consist of scientists who adhere to the highest ethical standards. We believe that Dennis C. Paustenbach does not meet those tests.

Thank you. If you need any more information, please let me know.

Sincerely,

Richard Wiles
Executive Director

[1] http://www.chemrisk.com/team/paustenbach.htm
[2] Andrew Schneider, “Pressure at OSHA to Alter Warning,” The Sun (Baltimore, Md.), Nov. 20, 2006.
[3] http://www.cspinet.org/integrity/index.html
[4] http://www.chrysotile.com/en/chrysotile/controversy/default.aspx
[5] http://www.chrysotile.com/en/conferences/speakers/Dennis_Paustenbach.aspx
[6] Peter Waldman, “Study Tied Pollutant to Cancer, Then Consultants Got Hold of It.” The Wall Street Journal, Dec. 23, 2005.
[7] http://www.ewg.org/reports/chromium

www.ewg.org is the website for both Environmental Working Group and EWG Action Fund
Copyright 2006, EWG Action Fund. All Rights Reserved.
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NIOSH advisory panel corrupted by asbestos, mesothelioma peddlers

If at First You Find the Truth, Try, Try Again

Under the guise of scientific inquiry and worker safety, a taxpayer funded effort is helping corporate America avoid legal responsibility for poisoning hundreds of thousands of Americans with asbestos. The National Institute for Occupational Safety and Health has proposed a roadmap that purportedly seeks to minimize the potential for asbestos disease.[1] In fact, the roadmap and its vast melding of tax dollars, federal bureaucracy, and industry cronies seek to protect asbestos defendants from valid claims by mesothelioma victims by showing that chrysotile asbestos is harmless, in contravention of almost one hundred years of clinical research.

The only two significant remaining issues for asbestos manufacturers after more than a century of wantonly poisoning millions—and earning billions—are defending mesothelioma lawsuits and defeating a ban on asbestos. The reasons are simple: asbestos lawsuits have bankrupted more than 85 companies since 1976, with more sure to follow,[2] and asbestos is still a profitable poison to sell in this country.[3]

These are not your grandfather’s bankruptcies, however, where bankruptcy meant that the company got liquidated, laid off all its employees, and wrecked the local economy.[4] The asbestos bankruptcy sham isn’t really a bankruptcy at all. It’s a legal sleight-of-hand that spins off the corporation’s legal liability by creating a trust fund to “compensate” victims. The sick and dying victims are then forced to hash it out with corporate lawyers, trust bureaucrats, and insurance companies, while being deprived of getting justice via direct lawsuits against the poisoner. The original mammoth bankrupt, Johns-Manville, has emerged from faux bankruptcy and today enjoys over $2.5 billion in annual sales.[5] An analysis of asbestos bankruptcies shows that the spin-off process has made them stronger, leaner, and profitable.[6] For the mesothelioma victims poisoned by these companies’ deliberate use of asbestos, the outcome has been less rosy. Victims of Johns-Manville who thought that they would be compensated soon found that the trust fund was tottering on the brink of bankruptcy after a few short years—in the old-fashioned sense, of course—so that they received only a pittance of the pittance they’d originally been promised.[7]

Not-so-covert Operation

The NIOSH roadmap is a sharp arrow pointed squarely at the heart of mesothelioma victims. Asbestos defendants know that there is no asbestos litigation crisis. There is no logjam in the courts, courts are not buckling under the weight of the asbestos caseload, and the peak of cases has passed.[8] Since faux-bankruptcies allow companies to quickly spin off their asbestos liabilities, and since the only detailed review of asbestos litigation as it relates to the supposed litigation crisis decisively concludes that there is none,[9] the only two issues left on the table are mesothelioma lawsuits and the ability to keep peddling the poison for a profit.

Mesothelioma litigation is one of the only avenues to the courthouse left for asbestos victims, and to get there the claimant usually has to die, since mesothelioma has the poorest of prognoses. But once in court, the victim has a good chance of getting some form of justice in the few states that haven’t shut the courthouse door to asbestos victims. Con Edison and Long Island Lighting Co. in New York got tagged with a $41 million verdict[10] a few years back, and defendants live in terror of the eight-digit judgments that outraged juries hand down in select jurisdictions.

When a patient with mesothelioma worked in the right job and got exposed to asbestos from the right products, he has a great case because the only cause of mesothelioma is asbestos. Unfortunately, the price for his great case is typically a slow and painful death. Asbestos manufacturers that have not yet sought faux-bankruptcy protection have therefore made it their single biggest priority to prove that even though asbestos indisputably causes mesothelioma, “their” type of asbestos does not.

Enter NIOSH and the roadmap.

Truth or Consequence?

Science has been political since Galileo recanted to the Inquisitors-General. But from the time the great astronomer retracted his heliocentric ideas in 1633, the general trend has been to insist on greater objectivity and less politics in science. Federal agencies like the EPA and NIOSH have historically been regarded as purveyors of reasonably de-politicized scientific inquiry. The Bush administration, however, has fast-tracked governmental science right back to the 17th Century.

Industry has seized on a number of administration initiatives as an indication that the time is ripe to churn out some old-fashioned junk science on the issue of how much of what kind of asbestos causes what kind of cancer how often in whom. The administration has favored junk science initiatives that cover a wide range of health and science related issues, and that have encouraged industry operatives with a wink and a nod about the new direction of science in government.

With respect to global warming, the administration’s strategy has been to question it at every turn.[11] The core policy of the administration has been to increase fossil fuel consumption while playing semantic games that exacerbate the problem,[12] if there is a problem, which they deny. Even when the EPA endorsed the idea that human activities such as oil refining, power plants, and automobile emissions are important causes of global warming, Bush dismissed them as “bureaucrats.”[13] Stem cell research, another province of hard science, has met with great resistance from the President. In 2001 he limited federal funding for embryonic stem cell research to cell lines already in existence, but the twenty lines still in use have become genetically degraded and are now ill-suited for research.[14] Bush’s non-scientific decision flew in the face of the National Institutes of Health, who have concluded that research on human embryonic stem cells offers great promise for curing Parkinson’s disease, heart disease, Alzheimer’s disease, spinal cord injury, and diabetes.[15] An equally blind and cynical eye was turned to mercury emissions,[16] tobacco,[17] air pollution,[18] and science in general, as the President declared his ideas about intelligent design on a scientific par with those of Charles Darwin by insisting they be taught in the classroom.[19] Asbestos industry operatives have been keenly watching the presidency for cues as they ramp up their assault on well-established notions of the asbestos toxicity in the waning days of the Bush Administration.

Silence of the Dead

Junk science and suppression of data are old friends to the asbestos industry. Chronicling the lies and cover-ups by asbestos defendants would occupy thousands of pages, and has been reviewed in depth by Castleman,[20] among others. Legal discovery in litigation has been responsible for uncovering much of the hard proof that of wrongdoing by the asbestos defendants. A brief recap, however, is appropriate because what is happening in the 2007 NIOSH roadmap bears uncanny resemblance to what happened decades ago.

In the 1920’s the medical community recognized that the fibrotic lung condition later known as asbestosis was caused by, of all things, exposure to asbestos.[21] By 1933, hired gun scientist, physician, and public health expert Anthony Lanza told asbestos company doctors that he didn’t think the hazards of asbestos warranted warning labels or posters in view of the “extraordinary” legal repercussions of telling the truth.[22] The asbestos industry, with its lawyers, insurers, and hired scientists, laid the foundation in the early 30’s for future concerted action to conceal research findings about asbestos and cancer.[23] In addition to doctoring scientific studies, publishing redacted science in peer-reviewed journals, and having asbestos industry business managers review and edit scientific research,[24] the history of America’s worst public health disaster has been largely caused by industry fraud.

Past behavior is always a useful referent for future performance. As NIOSH embarks on its industry-approved roadmap, it is helpful to remember that the strategy for asbestos companies has always centered on delay. In 1950, asbestos corporate officials had already committed to a firm policy of “epidemiology” and “causation,” the very two issues still being “debated” more than half a century later. In recommending an epidemiologic approach, the medical officer for Johns-Manville also opined that, “We would be wise to wait until we have proof of no causal relationship between asbestosis and pulmonary cancer…”[25]

It’s 2007, and the draft language from NIOSH’s roadmap indicates that they’re still waiting: “Yet, as we enter the 21st Century, many questions and areas of scientific uncertainty remain…Most importantly, the Roadmap outlines a research program that will provide answers to current scientific questions, reduce scientific uncertainties, and provide a sound scientific foundation for future policy development.”[26]

Johns-Manville couldn’t have said it better.

Endless Doubt

Asbestos defendants have a simple strategy for defeating valid mesothelioma claims in court: raise the level of uncertainty about science in order to keep it from the jury. Judges have been reluctant to keep out evidence where reasonable scientists disagree. So the asbestos defendants have chosen to raise the level of uncertainty about science in order to delay the use of knowledge about chrysotile toxicity for purposes of OSHA decision-making, and to limit public awareness of an issue affecting public or environmental health.

The backbone of the strategy to bring NIOSH to its knees vis-à-vis asbestos science begins with the insidious Information Quality Act, the brainchild of anti-regulation, pro-business lobbyist, trade council hack, voyeur, and self-confessed “dirty old man” Jim Tozzi.[27] The American Chamber of Commerce claimed that the law would “have a revolutionary impact on the regulatory process.”[28] Public interest groups claim that it has become a tool that special interest groups can use to avoid regulation forever.[29] Both have been proven correct.

With regard to asbestos science the jury is already in—or out and not coming back, if you’re a mesothelioma victim—on whether the act exists to promote quality data or exclude good science from agency regulations. On August 19, 2003, the asbestos defense firm Morgan, Lewis and Bockius[30] filed a petition with the EPA challenging a 1986 publication, “Guidance for Preventing Asbestos Disease among Auto Mechanics.”[31] Morgan Lewis claimed that the publication, known as EPA’s Gold Book, flunked the requirements of the Information Quality Act. Pursuant to the act, they claimed the data was inadequate, inappropriate, outdated, and in conflict with subsequent studies. Then they launched an all-out attack on the Gold Book claiming that verification of the publications origins, preparations, funding, review, and approval of the booklet are unknown.

Why all this fuss about an EPA publication that says in plain language:

1. Asbestos disease should be prevented among auto mechanics

2. Asbestos causes disease

4. Asbestos is easy to breathe and ingest

5. Proper work practices will reduce exposure

The fuss, of course, is that the automotive industry is terrified of mesothelioma lawsuits from auto mechanics. Brakes and clutches contain chrysotile asbestos. If chrysotile is dangerous enough for the government to warn, then the companies may ultimately be liable for their failure to warn—especially since they knew of the danger. The only solution, as they see it, is to prove that it’s not dangerous, or that the science is so complex and uncertain that they couldn’t have known.

Morgan Lewis’s challenge framed the innocuous publication as one intended to change the work-behavior practices of an entire industry and, because it relied on information from scientific sources, as one that must meet the rigorous standard for “influential information.” The key admission as to what was really driving their concern over the publication, however, was Morgan Lewis’s note that during litigation the Gold Book is routinely proffered as evidence of EPA’s current position and thinking on whether asbestos-containing friction products are dangerous to users.[32] Morgan Lewis cared zero about the quality of the data, and everything about its admissibility in court.

EPA caved in, approving most of the petition and promising to put out a new brochure, which it did.[33] OSHA then took over, as it came to do the bidding of the asbestos defendants and their lawyers. Unlike the Gold Book, which begins with the phrase “preventing asbestos disease among auto mechanics,” OSHA’s new document begins with a legal disclaimer: “[this bulletin] is not a standard or regulation, and it creates no new legal obligations.” The Gold Book talks about latency, asbestosis, mesothelioma, and lung cancer—evils caused by asbestos beyond any shred of scientific doubt, and the book instructs “there is no known level of exposure to asbestos below which health effects do not occur.” In contrast, OSHA’s 2006 bulletin includes exactly 27 words about health effects of asbestos. The document assures readers that asbestos use is declining, that newer cars may not use such products, and that nothing in the bulletin is to be taken as a standard, requirement, or regulation. It’s more like free advice, worth pretty much what it costs.

And what about the scientific quality of the government’s new booklet under the Information Quality Act? The original Gold Book was documented with 37 footnotes. The new OSHA brochure? One.

Tilting the Panel

The NIOSH draft roadmap, developed with the help of NIOSH scientists and engineers with combined experience in toxicology, epidemiology, industrial hygiene, analytical chemistry, and other disciplines, is forty-seven pages long. It includes a glossary, extensive footnotes, graphs, and even a list of acronyms. But nowhere in the document does it provide the long list of names of the scientists, engineers, and others who supposedly developed the report.

Nor is this a harmless oversight. The roadmap’s peer review panel is carefully composed of three unabashed “chrysotile doesn’t cause meso” members, one asbestos victim advocate, and five members who have expertise in various areas. None is an advocate for the proven scientific proposition that chrysotile causes mesothelioma. Ann G. Wylie, mineralogist at the University of Maryland, most recently worked as the principal investigator for a $508,000 grant funded by GM, Chrysler-Daimler, and Ford,[34] in case anyone’s wondering where she stands on chrysotile asbestos as it relates to automotive brakes. Wylie also is an unabashed proponent of the idea that exposure limits need to be revised via reclassification of asbestos fibers[35]—and she’s not suggesting downward, either. This reclassification—or research, as it’s called in the roadmap—is precisely what NIOSH has been tasked by industry to do: allow lots of exposure to chrysotile.

Brooke Mossman from the University of Vermont is another rabid asbestos apologist on the peer review panel. In addition to a Scientific American article where she reminds readers that chrysotile is “safer” than other forms of asbestos, and that other countries find asbestos of great utility,[36] Mossman defends one of her papers by quoting an epidemiologist who suggests that chrysotile may not cause mesothelioma at all.[37] The real aim of the roadmap is to find a path out of the last century of medical research, and find a way back to the days when Dr. Lanza could authoritatively tell fellow physicians that there really was no need for warnings about asbestos. Unlike Lanza, who was at least honest enough to admit that the reason for suppressing scientific facts was fear of litigation, the new crop of NIOSH hacks are hell-bent on simply denying the science.

In case the panel’s hue in terms of chrysotile toxicity weren’t sufficiently in favor of asbestos defendants, Morton Lippman also came along for the ride. Lippman believes that any fiber less than 5µ (happens to include most chrysotile fibers) is harmless. When the Carpenter Report clearly explained that even though short fibers might be less carcinogenic than long fibers, the fact that short fibers greatly outnumbered long fibers in Lower Manhattan after 9/11 and thus might cause more disease than long ones, Lippman accused Carpenter of “fear-mongering” in raising the short fiber issue.[38]

Since the NIOSH roadmap covers an extraordinary scope—“a research program that will provide answers to the current scientific questions, reduce scientific uncertainties, and provide a sound scientific foundation for future policy development”—it is remarkable that three pure pro-chrysotile reviewers would be on the peer review panel of only nine people, unless of course the real purpose of the roadmap was not to provide answers to current scientific questions but to chart a course for GM, Ford, and Chrysler-Daimler so that they may continue using chrysotile in their brakes and clutches, while helping chrysotile defendants avoid liability in court.

So How Dangerous IS Chrysotile?

Given the 3,000-4,000 Americans who die every year from mesothelioma, and have been doing so for decades, that the question is being asked at all is an offense against humanity. While asbestos defendants in this country dredge up the old arguments about the harmlessness of chrysotile, the rest of the world is working overtime to ban it. As of 2007, chrysotile has been banned by Iceland, Norway, Denmark, Sweden, Switzerland, the Netherlands, Finland, Italy, Germany, Kuwait, France, Poland, Monaco, Belgium, Saudi Arabia, Lithuania, the United Kingdom, Ireland, Brazil, Latvia, Chile, Argentina, Spain, Luxembourg, Uruguay, Australia, Honduras, South Africa, Japan, Cyprus, the Czech Republic, Estonia, Greece, Hungary, Lithuania, Malta, Portugal and Slovakia, Egypt, Jordan, Croatia, New Caledonia, Gabon, and the Seychelles.[39]

What do they know that we don’t? Nothing.

The World Health Organization classifies chrysotile as a carcinogen, period.[40] The International Agency for Research on Cancer is emphatic that it is not possible to assess whether there is an exposure level below which an increased risk of cancer will not occur.[41] The IARC classifies chrysotile as a carcinogen, and clearly states that although other types of asbestos create a higher risk for mesothelioma, some cases of mesothelioma do occur as a result of exposure to chrysotile.[42]

While asbestos defendants gleefully seize on the fact that chrysotile isn’t the most potent cause of mesothelioma, they forget that OSHA and EPA’s mandates aren’t only to ban the most potent causes of mesothelioma, but to make the workplace safer. Chrysotile is a carcinogen, case closed. From an occupational safety regulatory standpoint, what difference does it make to NIOSH whether mechanics are more likely to get mesothelioma or lung cancer? The substance is clearly dangerous, so get rid of it.

The answer, of course, is that the NIOSH roadmap is not set up to get asbestos carcinogens out of the workplace—everyone, even its most rabid apologists, agrees that chrysotile is a carcinogen. The NIOSH roadmap is, rather, set up to prove that chrysotile doesn’t cause mesothelioma. A greater perversion of a workplace safety research institute could hardly be imagined.

However at odds with public health or occupational safety, the real NIOSH inquiry is “Does this otherwise lethal carcinogen also cause mesothelioma?” The answer is also “yes.” A 25-year longitudinal study in China conducted by Chinese, Japanese, and American researchers showed that chrysotile alone causes mesothelioma. [43] This debunks the industry claim that only non-chrysotile forms of asbestos are to blame, and it confirms what doctors have been seeing for a century: even if chrysotile is less deadly, when the concentrations are high enough it causes lots and lots of mesothelioma.

NIOSH’s mandate is to protect workers. Abating asbestos and strictly enforcing dust suppression laws saves lives. Supporting the Ban Asbestos Act and putting teeth into workplace safety regulations fit neatly with OSHA’s mission. Empanelling junk scientists and churning out draft roadmaps fit the mission of asbestos defendants seeking a silver bullet to slay products liability litigation and to let them continue hawking their deadly wares.

Can We Please Go Home?

There is no compelling scientific, regulatory, medical, or policy reason to invest public money in an effort to establish that chrysotile doesn’t cause mesothelioma. Such research seeks to exculpate the fiber types that were used in 95% of all commercial and industrial applications, usage levels that fit neatly with the thousands of mesothelioma deaths every year in this country, and fit even more neatly with the Chinese study that shows how more exposure will lead to more mesothelioma.

No research will ever exculpate asbestos defendants’ products as pure chrysotile, because reasonable scientists differ over whether pure chrysotile even exists.[44] In addition, most of the asbestos used through the 1970’s, which is the source of the current mesothelioma scourge, was contaminated with amphibole/tremolite fibers. Sixty years ago asbestos manufacturers tried to escape blame for the public health crisis by pointing the finger at South African blue asbestos. Now they’re doing it again, except this time it’s with taxpayer dollars and the weight of a federal agency.

NIOSH should stop wasting resources on its sham roadmap. NIOSH should start investing money in finding a cure for mesothelioma. NIOSH should use its resources to come up with scientific findings that will help OSHA make the workplace safer by banning asbestos products. It really is that simple.


[1] Middendorf, Paul, Ralph Zumwalde, and Robert Castellan, “Asbestos and other mineral fibers: a roadmap for scientific research,” by on behalf of the NIOSH Mineral Fibers Work Group, Feb. 2007

[2] J.T. Thorpe: A Case Study, Brian L. Davidoff and Jeanne C. Wanlass, www.Lawjournalnewsletters.com, April 2007

[3] Virta, Robert L., Asbestos: Geology, Mineralogy, Mining, and Uses, U.S. Geological Survey, 2002, http://pubs.usgs.gov/of/2002/of02-149/of02-149.pdf. “In the U.S., the major use in roofing compounds (62%), followed by gaskets (22%) and friction products (11%).

[4] Mayerson, Marc, InsuranceScrawl.com, Mar. 2006. The first step in an asbestos-driven bankruptcy is to take the asbestos claims stream and estimate its value. The debtor then needs to satisfy that creditor claim in the bankruptcy, which it does by setting up a trust and funding it with cash (from itself and sometimes its corporate parent), stock, and preexisting insurance rights. The debtor receives a channeling injunction that bars the assertion of any asbestos-related claim against itself (and sometimes against non-debtors, see Susan Power Johnston and Katherine Porter, Extension of Section 524(g) of the Bankruptcy Code to Nondebtor Parents, Affiliates, and Transaction Parties, 59 Business Lawyer 511-12 (2004)), and the injunction furthermore funnels all claims to the trust. In other words, the debtor is able to emerge from bankruptcy shorn of its asbestos liabilities without fear of any future claims. The trust in turn is charged with resolving the asbestos claims and sets up an administrative compensation process, usually with relaxed standards of proof, to “adjudicate” the tort claims. The claimant may have the right further to bring an action in court, though with no ability to seek punitive damages for example. This is the model that was used in the Manville bankruptcy and was confirmed, expanded, and modified by Congress in 1994 when the bankruptcy code was amended with the addition of section 524(g), 11 U.S.C. § 524(g), a provision specially designed to deal with asbestos-driven bankruptcies. While certain procedural and substantive changes were implemented in 524(g), from the debtor’s perspective one key was that 524(g) made clear that future claims, claims by persons exposed to asbestos but who at the time of the bankruptcy filing had no legal claim, would have their claims channeled to the trust as well. Dealing with “futures” has been the Achilles heel of several non-bankruptcy deals in the class-action context, Ortiz v. Fibreboard Corp., 527 U.S. 815 (1999); Amchem v. Windsor, 521 U.S. 591 (1997), so the express conferral of power on bankruptcy courts to limit the right to sue of future claimants was quite significant. [Insurance Scrawl was profiled in The Wall Street Journal’s “Guide to the Blogs Insiders Read to Stay Current.” (11/16/05), and described as “influential” and a “must read,” for keeping “editorializing to a minimum,” while providing analysis with “weight” that “dissect[s]” court opinions and addresses the “nuances.”]

[5] SEIDA annual report, 2005, http://www.seida.info/downloads/2005AnnualReport.pdf

[6] Benston, George J., Professor, “Financial Analysis of Companies that Filed for Chapter 11 Bankruptcy in 2000 and 2001 as a Result of Asbestos Obligations,” Oct. 2003, http://www.ewg.org/reports/asbestos/facts/fact2.php

[7] Zirin, James D., of Sidley Austin Brown & Wood, Dow Jones Company, 2001. To date, after some more judicial intervention, the trust has settled with an additional 55,000 claimants and paid a total of $2 billion to victims of asbestos exposure, mostly on a basis of 10 cents on the dollar.

[8] “Asbestos Cases in the Courts: No Logjam,” Public Citizen, Feb. 2006, http://www.citizen.org/documents/NoLogJam.pdf

[9] “Asbestos Cases in the Courts: No Logjam,” Public Citizen, Feb. 2006, http://www.citizen.org/documents/NoLogJam.pdf

[10] Croteau v. Consolidated Edison, No. 118793/01 (New York Co., N.Y., Sup. Ct.)

[11] The Guardian, April 4, 2004

[12] Mieszkowski, K., “Bush: Global warming is just hot air,” Salon, Sep. 10, 2004. “The core of the Bush policy was a voluntary goal of reducing emissions ‘intensity’ by 18 percent by 2012,” says Aimee Christensen, executive director of Environment 2004, a political action group. So what the policy really calls for—but does not require—is a mere 4 percent reduction in intensity. What’s lost in the discussion about “emissions intensity” says Christensen, is that actual greenhouse gas emissions will increase 12 percent. Compare that to the targets set by the Kyoto Protocol, which would have mandated that by 2012 the U.S. return to emission levels 7 percent below those of 1990, or the McCain/Lieberman Climate Stewardship Act, which asked that the U.S. return to year 2000 levels of emissions. Both those plans would result in actual reductions, not just intensity reductions. The Bush administration walked away from the first proposal on the international stage and opposed the second here at home.

[13] CBS/AP News, June 4, 2004, http://www.cbsnews.com/stories/2002/06/03/tech/main510920.shtml

[14] Los Angeles Times, March 20, 2007

[15] NIH, Stem Cells: Scientific Progress and Future Research Directions (June 2001)

[16] Committee policy hearing on administration’s proposed mercury emissions rules, July 9, 2004. “Vermont’s U.S. Senators Patrick Leahy and Jim Jeffords Friday led a hearing to examine the Bush Administration’s proposal on mercury emissions from power plants. The nation’s 1,100 coal-burning power plants emit about 48 tons of mercury each year, the largest unregulated U.S. source. Witnesses, including former Environmental Protection Agency (EPA) officials, testified that the Administration proposal allows for more mercury pollution than current law and is much less protective of public health. Jeffords, the ranking member of the Senate Environment and Public Works Committee said, “Sadly, the Bush Administration’s proposal on mercury pollution from power plants appears to do little to protect public health, especially in the short term. The proposed Administration rule calls for a permanent delay in serious reductions and would achieve far less in cleanup than is possible with today’s technologies and is required by the Clean Air Act. Also, it lets more than 200 power plants buy their way out of controlling these toxic emissions for 20 years or more.” http://leahy.senate.gov/press/200407/070904.html

[17] Washington Post, Mar. 22, 2007. The leader of the Justice Department team that prosecuted a landmark lawsuit against tobacco companies said yesterday that Bush administration political appointees repeatedly ordered her to take steps that weakened the government’s racketeering case. Sharon Y. Eubanks said Bush loyalists in Attorney General Alberto R. Gonzales’s office began micromanaging the team’s strategy in the final weeks of the 2005 trial, to the detriment of the government’s claim that the industry had conspired to lie to U.S. smokers.

[18] President George W. Bush, April 20, 2007, http://www.whitehouse.gov/infocus/environment/. “By encouraging cooperative conservation, innovation, and new technologies, my Administration has compiled a strong environmental record. This Earth Day, harmful air pollutant levels are down more than ten percent since 2001. Millions more Americans are drinking cleaner, safer water. We have removed hazardous fuels from more than 19 million acres of federal land. We have created, restored, or protected more than 2.5 million acres of wetlands, and we have conserved almost 200 million of acres of habitat through Farm Bill conservation programs. And we are taking positive steps to confront the important challenge of climate change. Our work is not done. We also have a responsibility to pass on to future generations our commitment to the environment.” Contrast this with an analysis of the Clear Skies plan that shows it will weaken and delay health protections already required under the law, set weaker targets for emissions of sulfur dioxide, mercury, and nitrogen oxides from U.S. power plants, fail to include a single measure to reduce or even limit the growth of carbon dioxide, and hamstring efforts to cut pollution from old coal-fired plants. Natural Resources Defense Council, Sep. 4, 2003, http://www.nrdc.org/air/pollution/qbushplan.asp.

[19] Washington Post, Aug. 3, 2005. President Bush invigorated proponents of teaching alternatives to evolution in public schools with remarks saying that schoolchildren should be taught about “intelligent design,” a view of creation that challenges established scientific thinking and promotes the idea that an unseen force is behind the development of humanity.

[20] Castleman, B., “Asbestos: Medical and legal aspects,” 1986

[21] “The Silence: The Asbestos Industry and Early Occupational Cancer Research—A Case Study,” Lilienfeld, David, M.D., American Journal of Public Health, 1991, Vol. 81, No. 6

[22] Id.

[23] Id.

[24] Id.

[25] Id.

[26] Asbestos and Other Mineral Fibers: A Roadmap for Scientific Research, NIOSH, Feb. 2007

[27] Washington Monthly, May 2004. Tozzi’s Information Quality Act, codified at 44 U.S.C. 3504(d)(1) and 3516, has led to suits challenging a government report on climate change and a National Institutes of Health study on diet, both of which represent state-of-the-art scientific work in their fields. The latter suit was recently filed by the Chamber of Commerce and the Salt Institute, an industry group, as a strategic test case to establish judicial review under the Data Quality Act. Slowly, Tozzi and allies are laying the groundwork for a broader assault on the regulatory state. Data quality, says Kovacs, is going to have “a revolutionary impact on the regulatory process.”

[28] The Information Quality Act: OMB’s Guidance and Initial Implementation, Congressional Research Service, Sep. 17, 2004.

[29] Id.

[30] Information Quality Act petition, Aug. 19, 2003

[31] EPA publication, June 1986

[32] Information Quality Act petition, id.

[33] Asbestos—Automotive Brake and Clutch Repair Work, OSHA, Jul. 26, 2006, http://www.osha.gov/dts/shib/shib072606.html#1

[34] Ann G. Wylie curriculum vitae

[35] Wylie, A., The Importance of Width in Asbestos Fiber Carcinogenicity and its Implications for Public Policy, American Industrial Hygiene Association journal, Jun. 1993. “Evidence from human epidemiology, experimental animal implantation and inoculation studies, and lung burden studies shows that fibers with widths greater than 1 µm are not implicated in the occurrence of lung cancer or mesothelioma. Furthermore, it is generally believed that certain fibers thinner than a few tenths of a micrometer must be abundant in a fiber population in order for them to be a causative agent for mesothelioma. These conclusions are fully consistent with the mineralogical characteristics of asbestos fibers, which, as fibrils, have widths of less than 1 µm and, as bundles, easily dissagregate into fibrils. Furthermore, the biological behavior of various habits of tremolite shows a clear dose-response relationship and provides evidence for a threshold between fiber width and tumor experience in animals. Public policy in regulating mineral fibers should incorporate this knowledge by altering the existing federal asbestos fiber definitions to reflect it.”

[36] “Asbestos Revisited,” Scientific American, July 1997

[37] Environmental Health Perspectives Volume 102, Number 5, May 1994

[38] NYCOSH Update on Safety and Health, Vol. VIII, No. 22, March 16, 2005

[39] International Ban Asbestos Secretariat, 2006

[40] International Agency for Research on Cancer (IARC), 1998, Summaries & Evaluations: ASBESTOS
(Actinolite, amosite, anthophyllite, chrysotile, crocidolite, tremolite), (Group 1)

[41] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 14, Asbestos, http://monographs.iarc.fr/ENG/Monographs/vol14/volume14.pdf

[42] IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 2, Some Inorganic and Organometallic Compounds, http://monographs.iarc.fr/ENG/Monographs/vol2/volume2.pdf

[43] Cancer Mortality among Workers Exposed to Amphibole-free Chrysotile Asbestos, American Journal of Epidemiology Vol. 154, No. 6 : 538-543, 2001. The issue of whether exposure to chrysotile asbestos alone, without contamination from amphibole asbestos, causes lung cancer and mesothelioma was investigated in a 25-year longitudinal study (1972–1996) in Chongqin, China. The study cohort comprised 515 male asbestos plant workers exposed to chrysotile only; the control cohort included 650 non-dust-exposed workers. The results of analysis in which the proportional hazards model was used indicated that mortality due to all causes, all cancers, and lung cancer was related to asbestos exposure; the relative risks, adjusted for age and smoking, were 2.9, 4.3, and 6.6, respectively. Fiber concentrations in the raw material section and the textile section of the plant were 7.6 and 4.5 fibers/ml, respectively. Because of differences between the study and control plants, the authors also compared various sections of the asbestos plant that had different levels of dust exposure. The adjusted relative risk of lung cancer was 8.1 for workers exposed to high versus low levels of asbestos. Two cases of malignant mesothelioma, one pleural and the other peritoneal, were found in the asbestos cohort. These results suggest that heavy exposure to pure chrysotile asbestos alone, with negligible amphibole contamination, can cause lung cancer and malignant mesothelioma in exposed workers.

[44] Analysis of Amphibole Asbestos in Chrysotile and Other Minerals, Addison, J., and L.S.T. Davies, Annals of Occupational Hygiene, Vol. 34, No. 2, pp. 159-175, 1990. Chrysotile asbestos and many other mineral raw materials contain amphibole minerals which may be asbestiform. There is currently no analytical method which will detect the presence of amphibole at sufficiently low limits to preclude the possibility of inadvertent exposure of persons handling these materials to hazardous airborne fiber concentrations. A method of chemical digestion of chrysotiles has been tested with regard to the determination of their tremolite contaminant content and this has been applied to a range of chrysotile and other minerals. The method improves the sensitivity of the amphibole analysis at least 10-fold giving detection limits of 0.01–0.05% in chrysotile by X-ray diffractometry (XRD). The difficulties arising from compositional and morphological variations are discussed in the context of the potential hazards from airborne fibers and the relative values of analyses by XRD, infra red spectrophotometry (IR) and electron microscopy. It is concluded that XRD and IR are useful as screening methods for the detection of amphibole in chrysotile but other materials should be analyzed by optical or electron microscopy.

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